Thank you, that got me the right info on ConTeXtgarden. I now use \tf and:
\starttypescript [sans] [optima]
\setups[font:fallback:sans]
\definefontsynonym [Sans] [file:Optima.ttc(Optima Regular)] [features=default]
\definefontsynonym [SansBold] [file:Optima.ttc(Optima Bold)] [features=default]
\definefontsynonym [SansItalic] [file:Optima.ttc(Optima Italic)] [features=default]
\definefontsynonym [SansBoldItalic] [file:Optima.ttc(Optima Bold Italic)] [features=default]
\stoptypescript
\definetypeface [optima] [ss] [sans] [optima] [default]
\definetypeface [optima] [rm] [serif] [optima] [default]
\definetypeface [optima] [tt] [mono] [modern] [default]
\definetypeface [optima] [mm] [math] [optima] [default]
\setupbodyfont [optima]
As I now understand it, I have now defined the typescript for sans, but created a setup that sans is the fallback. I have also defined rm, tt and mm explicitly.
But my guess is that if I had used ss instead of rm everywhere in my code it would have worked as well.
G