As an experiment, I'm trying to duplicate a sample InDesign document with ConTeXt. I'm getting the overall layout (though my image positions need tweaking), but I'm having some problems with the fonts.
\setuppapersize[card][card]
\definetypeface[impact[rm][serif][mpact regular][default]
\definetypeface[minion][rm][serif][Minion Pro Regular][default]
\definetypeface[myriad][rm][serif][Myriad Pro Regular][default]
\setupcolor[cmyk]
\setupcolors[state=start]
\definecolor[red][c=0,m=.87,y=.87,k=0]
\definelayer[textbox][width=\paperwidth,height=\paperheight]
\setupbackgrounds[page][background=textbox]
\def\starttextbox
{\dosingleargument\dostarttextbox}
\def\dostarttextbox[#1]%
{\def\stoptextbox{\setlayerframed[textbox][width=6cm,align=normal,frame=off,#1]{\getbuffer[textbox]}}%
\startbuffer[textbox][starttextbox][stoptextbox]}
\starttext
%\starttextbox[x=12pt,y=20pt,width=768pt]
%\useexternalfigure[ador1][Chrysanthemum.jpg][width=768pt]
%\placefigure[here,force][]{none}{\externalfigure[ador1]}
%\stoptextbox
\starttextbox[x=195.3pt,y=115.2pt,width=560.7pt]
\switchtotypeface[impact][48pt]
\midaligned{Yo, First!}
\stoptextbox
\page[empty]
\starttextbox[x=447.6pt,y=228pt,width=229.5pt]
\switchtotypeface[minion][14pt]%
Title. First Last \\
Company \\
Street Address \\
City, State, ZIP
\stoptextbox
\starttextbox[x=85.2pt,y=228pt,width=229.5pt]
\switchtotypeface[minion][14pt]%
Dear First,\\
\blank
Are you aware that now is the {\bf winter of our discontent}? It's been made {\it glori}\color[red]{\it ous} \color[red]{\bi sum}{\bi mer} by this son of York.\\
\blank
I say let's put it back the way it was. Are you with me, Last?\\
\blank
Good.\\
\blank
-pd
\stoptextbox
%\starttextbox[x=85.2pt,y=62.4pt,width=229.5pt]
%\useexternalfigure[ador2][pd-logo-nobg.eps][scale=245.37]
%\placefigure[here,force][pdlogo]{none}{\externalfigure[ador2]}
%\stoptextbox
\starttextbox[x=249.6pt,y=62.4pt,width=298.8pt]
\switchtotypeface[myriad][20pt]%
Peter Davis\\
Head Hoo-Ha\\
Hoo-Ha House, Inc.\\
123 Fourfivesix St.\\
Lake Placebo, NY 12345-6789
\stoptextbox
\page[empty]
\stoptext