so this should work?
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\startuniqueMPgraphic{strikeme}
path p ; p := OverlayBox topenlarged -ExHeight bottomenlarged -ExHeight ;
draw llcorner p -- urcorner p withcolor OverlayColor ;
\stopuniqueMPgraphic
\defineoverlay[strikeme][\uniqueMPgraphic{strikeme}]
\def\strike#1{%
\ifmmode%
\mframed[background=strikeme,frame=off]{#1}%
\else%
\inframed[background=strikeme,frame=off]{#1}%
\fi}
\starttext
\startformula
{\strike2a + \strike ab \over \strike a} = a
\stopformula
Works in text, \strike{two}too!
\stoptext