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I have come up with part answers to my two questions. The remaining unanswered question is in the final line. The question I can now answer, after some experimenting, is how to ensure that I can use small caps as part of the Alegreya family when I need to do so. This is how my definitions now look (the solutions are highlighted): \definefontfamily [mainface] [rm] [alegreya] *[sc=file:alegreyasc-bold]* \definefontfamily [mainface] [ss] [dax][tf=file:dax-regular] \definefontfamily [mainface] [mm] [alegreya] \setupbodyfont[mainface] This now enables me to do: {\sc text in small caps} and the rest of the paragraph as normal (alegreya-regular)... I also now know, using the same type of solution above, that I can use two different weights of Dax, as follows: \definefontfamily [mainface] [ss] [dax][tf=file:dax-regular,*bf=file:dax-medium*] which enables me to do as follows: {\ss\bf My subheading} and it will be in Dax-medium font. But I also want to be able to use a second sans serif font, namely ITCAvantGardePro-Md. Can I have two 'mainface' definitions for [ss]? Or how would I achieve this? Julian